Endocrine Abstracts

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated beneficial effects on cardiovascular and renal events in patients with type 2 diabetes mellitus. The mechanisms underlying these effects are not fully elucidated. Aim of this study was to investigate whether empagliflozin is able to affect arterial stiffness/pulse wave velocity in type 2 diabetic patients.Methods: Pulse wave velocity and other parameters of arterial stiffness were...

Introduction: Non functioning pituitary adenomas (NFPAs) are the most common type of pituitary tumors and are often invasive, resulting in high relapse rates. The post-surgical treatment for NFPAs remains a debated issue and include radiation therapy and additional surgery. Several clinical studies have demonstrated that dopaminergic and somatostatin receptors (SSTRs) are widely expressed in NFPAs. Furthermore, recent studies have shown the potential effectiveness of somatosta...

Metabolic Syndrome (MetS) has been frequently associated with an overall inflammation status, called “metaflammation”, including atherosclerosis and non-alcholic steatohepatitis (NASH), In this study we aimed to evaluate the relationship between intra-prostatic inflammation and NASH in a cohort of patients affected by BPH. Between January 2012 and January 2016, 132 consecutive patients with BPH-related lower urinary tract symptoms (LUTS) who underwent transurethral r...

Objective: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, with a female to male ratio of 3:1. Currently most patients with PHPT are asymptomatic. However, data about the gender impact on the clinical presentation of PHPT are lacking.Methods: We evaluated the difference in symptoms and biochemical parameters between men and women with PHPT in a single center series of 417 patients.Results: Male PHP...

Introduction: Cortisol autonomy may be frequently demonstrated in patients with adrenal incidentaloma and this has been associated to increased cardiovascular (CV) risk. However, only few data are available on CV events and related mortality in such patients. Aims of the study were: 1) to stratify CV events and mortality by the degree of cortisol secretion; 2) to evaluate the effect of adrenalectomy on CV events and mortality.Methods and Design: Data of ...

Introduction: Urinary free cortisol (UFC) determination has suboptimal sensitivity (SE) and specificity (SP) especially in mild Cushing’s syndrome (CS).Aim: To determine the performance of UFC and its metabolite cortisone (UFE) measured using accurate assays such as HPLC and LC–MS/MS in diagnosing patients with CS.Patients and methods: Sixty-seven patients with CS were compared to 49 sex- and age-matched non-CS. UFF and U...

Introduction: The diagnosis of Cushing’s syndrome (CS) might be challenging especially in ACTH-dependent CS when it comes to detect the origin of ACTH secretion.Materials and methods: We retrospectively recorded data about 170 patients with ACTH-dependent CS (149 CD, 21 EAS) referring to two Endocrinology Units. We focused especially on the performance of 3 dynamic tests: the dexamethasone 8 mg overnight challenging (HDDST), the CRH and the desmopre...

Background: There is growing evidence supporting TNF-related apoptosis-inducing ligand (TRAIL) involvement in weight and body composition regulation, which are classically influenced by thyroid hormones. This study aimed at investigating the relationship between thyroid hormones and TRAIL.Methods: Circulating TRAIL was measured in 40 controls, 40 hyperthyroid, and 25 hypothyroid patients before and after their respective treatments. In the same patients ...

Introduction: Reduction in bone mineral density (BMD) is a common feature in primary hyperparathyroidism (PHPT), involving mostly cortical site. In the management of asymptomatic PHPT (aPHPT), guidelines indicate measuring BMD at lumbar spine, hip and forearm and surgery is recommended for patients with a T-score of −2.5 or less at one of these sites. However, BMD at forearm is not always performed.Aim: Our aim was to evaluate the impact o...